Julie Parsonnet

Publication Details

  • Helicobacter pylori virulence and genetic geography SCIENCE Covacci, A., Telford, J. L., Del Giudice, G., Parsonnet, J., Rappuoli, R. 1999; 284 (5418): 1328-1333


    Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.

    View details for Web of Science ID 000080430600045

    View details for PubMedID 10334982

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