Glen Lutchman
Publication Details
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Mutation rate of the hepatitis C virus NS5B in patients undergoing treatment with ribavirin monotherapy.
Gastroenterology. 2007; (5): 1757-66
Error catastrophe from an increase in mutation rate may be a possible mechanism of action of ribavirin in chronic hepatitis C (CHC). We sought to evaluate the mutagenic potential of ribavirin in vivo and to determine if conserved regions of hepatitis C virus (HCV) NS5B are mutated during ribavirin therapy.
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