Gerald Reaven, MD

Publication Details

  • Antihyperglycemic activities of cryptolepine analogues: An ethnobotanical lead structure isolated from Cryptolepis sanguinolenta JOURNAL OF MEDICINAL CHEMISTRY Bierer, D. E., Dubenko, L. G., Zhang, P. S., Lu, Q., Imbach, P. A., Garofalo, A. W., Phuan, P. W., Fort, D. M., Litvak, J., Gerber, R. E., Sloan, B., Luo, J., Cooper, R., Reaven, G. M. 1998; 41 (15): 2754-2764


    Cryptolepine (1) is a rare example of a natural product whose synthesis was reported prior to its isolation from nature. In the previous paper we reported the discovery of cryptolepine's antihyperglycemic properties. As part of a medicinal chemistry program designed to optimize natural product lead structures originating from our ethnobotanical and ethnomedical field research, a series of substituted and heterosubstituted cryptolepine analogues was synthesized. Antihyperglycemic activity was measured in vitro and in an NIDDM mouse model to generate the first structure-bioactivity study about the cryptolepine nucleus.

    View details for Web of Science ID 000074878000013

    View details for PubMedID 9667966

Stanford Medicine Resources:

Footer Links: