Chandra Ramamoorthy

Publication Details

  • Endothelial and leukocyte adhesion molecules in inflammation and disease BLOOD COAGULATION & FIBRINOLYSIS Winn, R., Vedder, N., Ramamoorthy, C., Sharar, S., Harlan, J. 1998; 9: S17-S22


    Injury associated with ischemia and reperfusion is a significant factor in a number of clinical diseases. We have completed a number of preclinical studies investigating the blockade of leukocyte adhesion molecules in ischemia-reperfusion injury. In our work and in the work of other investigators, monoclonal antibodies directed to CD18, P-selectin and L-selectin were effective in reducing ischemia-reperfusion injury to the rabbit ear and in reducing injury following hemorrhagic shock in both rabbits and nonhuman primates. Ischemia-reperfusion injury was also reduced by synthetic oligosaccharide sLe(x). These studies suggest that adhesion blockade might be effective in the clinical setting.

    View details for Web of Science ID 000074404300006

    View details for PubMedID 9662466

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