Samuel Strober

Publication Details

  • An alternate pathway for T cell development supported by the bone marrow microenvironment: Recapitulation of thymic maturation JOURNAL OF EXPERIMENTAL MEDICINE Garcia-Ojeda, M. E., Dejbakhsh-Jones, S., Weissman, I. L., Strober, S. 1998; 187 (11): 1813-1823


    In the principal pathway of alpha/beta T cell maturation, T cell precursors from the bone marrow migrate to the thymus and proceed through several well-characterized developmental stages into mature CD4+ and CD8+ T cells. This study demonstrates an alternative pathway in which the bone marrow microenvironment also supports the differentiation of T cell precursors into CD4+ and CD8+ T cells. The marrow pathway recapitulates developmental stages of thymic maturation including a CD4+CD8+ intermediary cell and positive and negative selection, and is strongly inhibited by the presence of mature T cells. The contribution of the marrow pathway in vivo requires further study in mice with normal and deficient thymic or immune function.

    View details for Web of Science ID 000074120200009

    View details for PubMedID 9607922

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