Sharon E. Williams PhD

Publication Details

  • Recovery in pediatric brain injury: Is psychostimulant medication beneficial? JOURNAL OF HEAD TRAUMA REHABILITATION Williams, S. E., Ris, M. D., Ayyangar, R., Schefft, B. K., Berch, D. 1998; 13 (3): 73-81


    To assess the effects of methylphenidate on attention, memory, behavior, processing speed, and psychomotor skills of children with closed head injuries.Double-blind, placebo-controlled, crossover design.An outpatient facility of a children's hospital medical center.Ten pediatric subjects identified through chart review. Subjects met baseline scores for hyperactivity (Conner's Hyperactivity Index greater than or equal to 60) and intellectual functioning (Verbal Intelligence Quotient greather than or equal to 70) and achieved minimal scores on two psychometric tests. All subjects evidenced head injury by focal lesions on computed tomography scan and/or sequelae reported at the time of injury. Severity of injury ranged from mild to severe. All subjects were medically stable at the time of testing. Mean time post injury was 2 years, 8 months.Administration of methylphenidate and placebo.Percentage change in scores was calculated to assess differences between baseline and end of methylphenidate/placebo trials.No significant differences between methylphenidate and placebo on measures assessing behavior, attention, memory, and processing speed.The results of the study call into question the effectiveness of methylphenidate in the pediatric head injury population.

    View details for Web of Science ID 000074042200007

    View details for PubMedID 9582180

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