Richard Sibley

Publication Details

  • Subsets of transgenic T cells that recognize CD1 induce or prevent murine lupus: Role of cytokines JOURNAL OF EXPERIMENTAL MEDICINE Zeng, D. F., Dick, M., Cheng, L. R., Amano, M., Dejbakhsh-Jones, S., Huie, P., Sibley, R., Strober, S. 1998; 187 (4): 525-536


    T cells with T cell receptor (TCR) transgenes that recognized CD1 on syngeneic B cells stimulated B cells to secrete immunoglobulins in vitro. The CD4+, CD8+, or CD4-CD8- T cells from the spleen of the TCR transgenic BALB/c donors induced lupus with anti-double stranded DNA antibodies, proteinuria, and immune complex glomerulonephritis in irradiated BALB/c nude mice reconstituted with nude bone marrow. Injection of purified CD4-CD8- T cells from the marrow of transgenic donors prevented the induction of lupus by the transgenic T cells. Transgenic T cells that induced lupus secreted large amounts of interferon (IFN)-gamma and little interleukin (IL)-4, and those that prevented lupus secreted large amounts of IL-4 and little IFN-gamma or IL-10.

    View details for Web of Science ID 000072160200009

    View details for PubMedID 9463403

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