Lawrence Steinman

Publication Details

  • Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms JOURNAL OF NEUROIMMUNOLOGY Gaur, A., Boehme, S. A., Chalmers, D., Crowe, P. D., Pahuja, A., Ling, N., Brocke, S., Steinman, L., Conlon, P. J. 1997; 74 (1-2): 149-158


    T-cells specific for a region of human myelin basic protein, amino acids 87-99 (hMBP87-99), have been implicated in the development of multiple sclerosis (MS) a demyelinating disease of the central nervous system. Administration of soluble altered peptide ligand (APL), made by substituting native residues with alanine at either positions 91(91K > A or A91) or 97 (97R > A or A97) in the hMBP87-99 peptide, blocked the development of chronic relapsing experimental autoimmune encephalomyelitis (R-EAE), in the SJL mouse. The non-encephalitogenic APL A91, appears to induce cytokine shifts from Th1 to Th2 in the target T-cells, whereas the encephalitogenic superagonist APL A97 causes deletion of the MBP87-99 responsive cells. Thus, single amino acid changes at different positions in the same peptide epitope can lead to APL capable of controlling auto-immune disease by different mechanisms.

    View details for Web of Science ID A1997WQ87100020

    View details for PubMedID 9119968

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