Stephen Galli

Publication Details

  • IgE regulates mouse basophil Fc epsilon RI expression in vivo JOURNAL OF IMMUNOLOGY Lantz, C. S., Yamaguchi, M., Oettgen, H. C., Katona, I. M., Miyajima, I., Kinet, J. P., GALLI, S. J. 1997; 158 (6): 2517-2521


    The binding of IgE to high-affinity IgE receptors (Fc epsilon RI) on the surface of mast cells and basophils primes these cells to secrete a panel of proinflammatory mediators upon subsequent exposure to specific Ag. We now find that the level of Fc epsilon RI expression on bone marrow basophils in mice infected with the nematode Strongyloides venezuelensis exhibits a strong positive correlation with the serum concentration of IgE, as was previously reported for human blood basophils. Moreover, the administration of IgE in vivo can significantly upregulate Fc epsilon RI expression on mouse basophils, and genetically IgE-deficient (IgE -/-) mice exhibit a dramatic (approximately 81%) reduction of basophil Fc epsilon RI expression compared with the corresponding normal (IgE +/+) mice. The finding that IgE can be a major regulator of mouse basophil Fc epsilon RI expression in vivo identifies a potentially important mechanism for enhancing the expression of effector cell function in IgE-dependent allergic reactions or immunologic responses to parasites.

    View details for Web of Science ID A1997WM43500003

    View details for PubMedID 9058781

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