Oliver O. Aalami, MD
Publication Details
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Differential transcriptional expression profiles of juvenile and adult calvarial bone.
Plast Reconstr Surg. 2005; (7): 1986-94
It has widely been observed that young children are capable of reossifying large calvarial defects, while adults lack this endogenous tissue-engineering capacity. The ability of juvenile animals to regenerate calvarial defects has been investigated in multiple animal models, including mice. In this study, the authors used cDNA microarrays to investigate the expression of osteogenesis-associated genes upstream and downstream of Runx2 in juvenile and adult mouse calvaria.
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