Michael Rothenberg
Publication Details
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Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice.
Gastroenterology. 2012; (5): 1195-1205.e6
Paneth cells contribute to the small intestinal niche of Lgr5(+) stem cells. Although the colon also contains Lgr5(+) stem cells, it does not contain Paneth cells. We investigated the existence of colonic Paneth-like cells that have a distinct transcriptional signature and support Lgr5(+) stem cells.
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