Christian Guilleminault

Publication Details

  • Insulin resistance and sleep-disordered breathing in healthy humans AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Stoohs, R. A., Facchini, F., Guilleminault, C. 1996; 154 (1): 170-174


    Fifty healthy, normotensive individuals (34 women) with a mean age of 44.3 +/- 13.2 yr and a mean body mass index of 27.1 +/- 5.4 kg/m2 were tested for the presence or absence of insulin resistance and sleep-disordered breathing. The hypothesis of this investigation was that insulin resistance is associated with sleep-disordered breathing. In vivo insulin action with determination of steady-state plasma glucose (SSPG) and insulin was measured using simultaneous intravenous infusion of somatostatin, glucose, and insulin via a Harvard pump. Determination of sleep-disordered breathing was performed through clinical assessment and portable nocturnal monitoring using a validated sleep apnea recorder. Individuals with > or = 10 hypoxic respiratory events per hour of sleep were significantly more insulin-resistant than subjects without sleep-breathing disorders. After adjusting the relationship between insulin resistance and sleep-disordered breathing for potential confounding variables, it was found that this relationship was entirely dependent on body mass.

    View details for Web of Science ID A1996UW82700029

    View details for PubMedID 8680675

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