Steven Foung

Publication Details

  • NEUTRALIZING ANTIBODY TO VESICULAR STOMATITIS-VIRUS (HTLV-I) PSEUDOTYPE IN INFANTS BORN TO SEROPOSITIVE MOTHERS JAPANESE JOURNAL OF CANCER RESEARCH Iwahara, Y., Sawada, T., Taguchi, H., Hoshino, H., Umemoto, M., Take, H., Foung, S., Miyoshi, I. 1993; 84 (2): 114-116

    Abstract:

    Breast feeding is the major route of mother-to-child transmission of human T-cell leukemia virus type I (HTLV-I). Our experiments with rabbits have shown that passive immunization is capable of blocking cell-to-cell infection of HTLV-I by blood transfusion or breast feeding. In this study, sera were collected serially from 3 infants born to seropositive mothers and were tested for the presence of neutralizing antibody to vesicular stomatitis virus (HTLV-I) pseudotype as well as antibodies to viral structural proteins. There was a good correlation between neutralizing and viral antibody titers, both of which were detectable until 3-6 months after birth. Whether maternally transmitted neutralizing antibody is protective against perinatal infection of HTLV-I remains to be studied.

    View details for Web of Science ID A1993KN14300003

    View details for PubMedID 8385083

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