Gerald Reaven, MD

Publication Details

  • WHY DOES INSULIN-RESISTANCE DEVELOP DURING MATURATION JOURNALS OF GERONTOLOGY Reed, M. J., Reaven, G. M., Mondon, C. E., Azhar, S. 1993; 48 (4): B139-B144

    Abstract:

    We compared skeletal muscle glucose uptake between young and mature rats. Hindlimb perfusions at insulin concentrations of 0, 100, 250, or 10,000 microU/mL were performed on male Sprague-Dawley rats at 5 weeks or 4 months of age. Basal glucose uptake, and glucose uptake at all insulin concentrations were significantly lower in the 4-month-old mature rats (p < .05). This difference was most pronounced at maximally stimulating insulin concentrations. Skeletal muscle insulin receptor binding, autophosphorylation, and tyrosine kinase activity did not differ between young and mature rats. Surprisingly, GLUT-4 glucose transporter content was significantly higher in several muscles of the mature rats (p < .05). Therefore, the decline in insulin-stimulated glucose uptake in hindlimbs of mature rats cannot be explained by decreased activity of these steps in the glucose transport system.

    View details for Web of Science ID A1993LL26100020

    View details for PubMedID 8315217

Stanford Medicine Resources:

Footer Links: