Uta Francke

Publication Details

  • GENE FOR A TISSUE-SPECIFIC TRANSCRIPTIONAL ACTIVATOR (EBF OR OLF-1), EXPRESSED IN EARLY B-LYMPHOCYTES, ADIPOCYTES, AND OLFACTORY NEURONS, IS LOCATED ON HUMAN CHROMOSOME-5, BAND-Q34, AND PROXIMAL MOUSE CHROMOSOME-11 MAMMALIAN GENOME MILATOVICH, A., Qiu, R. G., Grosschedl, R., FRANCKE, U. 1994; 5 (4): 211-215

    Abstract:

    Murine B lymphocytes, adipocytes, and olfactory neurons contain a DNA-binding protein that participates in the regulation of genes encoding tissue-specific components of signal transduction. Purification and cloning of this protein, termed early B-cell factor (EBF), from murine B lymphocytes and independent cloning of a protein, termed Olf-1, from olfactory neuronal cells revealed virtual complete amino acid sequence identity between these proteins. As a first step towards identifying a human genetic disorder or mouse mutation for which EBF could be a candidate gene, we have chromosomally mapped the corresponding locus in both species. By Southern hybridization analyses of somatic cell hybrid panels with murine cDNA probe, fluorescence chromosomal in situ hybridization (FISH) of human genomic clones, and analysis of recombinant inbred mouse strains, we have found single sites for EBF homologous sequences on human Chromosome (Chr) 5, band q34, and on proximal mouse Chr 11, in an evolutionarily conserved region.

    View details for Web of Science ID A1994ND31300004

    View details for PubMedID 8012110

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