Neil Gesundheit

Publication Details

  • DYNAMIC CHANGES OF GROWTH HORMONE-BINDING PROTEIN CONCENTRATIONS IN NORMAL MEN AND PATIENTS WITH ACROMEGALY - EFFECTS OF SHORT-TERM FASTING METABOLISM-CLINICAL AND EXPERIMENTAL Ho, P. J., Gesundheit, N., Wong, W. L., Huang, S. H., FRIBERG, R. D., Barkan, A. L. 1995; 44 (5): 667-672

    Abstract:

    Plasma concentrations of growth hormone (GH) and GH-binding protein (GHBP) were measured at hourly intervals in five healthy men and five patients with acromegaly during the fed state and after a 5-day fast. GHBP concentrations (both total and complexed with endogenous GH) were analyzed by the ligand-mediated immunofunctional assay (LIFA). Total GHBP was similar in both groups during the fed state (104.4 +/- 5.2 and 101.6 +/- 10.3 pmol/L), did not exhibit a diurnal rhythm, and was unchanged by fasting (91.9 +/- 5.4 and 109.9 +/- 10.5 pmol/L, respectively). However, the GHBP/GH complex concentration was significantly higher in acromegalics than in controls (41.0 +/- 2.8 v 18.0 +/- 2.2 pmol/L, respectively; P < .05), closely followed diurnal GH rhythm in normals, and was significantly correlated with mean 24-hour GH concentrations (r = .86, P < .01). We conclude that plasma concentrations of GHBP are stable throughout the day and are unchanged either by short-term calorie deprivation or by chronic exposure to high levels of endogenous GH. In contrast, GHBP/GH complex concentrations are altered both acutely and chronically by ambient GH.

    View details for Web of Science ID A1995QW97900017

    View details for PubMedID 7752917

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