C. Garrison Fathman

Publication Details

  • REGULATION OF AUTOIMMUNE-RESPONSE CURRENT OPINION IN IMMUNOLOGY Ridgway, W. M., Weiner, H. L., Fathman, C. G. 1994; 6 (6): 946-955

    Abstract:

    Recent work on such apparently disparate fields as T-cell receptor peptide-induced regulation, superantigens, antigen-induced tolerance, models of peripheral tolerance, apoptosis, and T-cell receptor antagonists demonstrates a similarity in immune response from a regulatory perspective. In many systems, a 'tolerance' pathway is observed, characterized broadly as an initial disturbance in the immune system, with a resulting predominance of effector cells, followed by a homeostatic response (often requiring CD8+ cells) which leads the effector population into T-cell receptor downregulation, T-cell inactivation, anergy and, often, eventual apoptotic death. In the regulated immune response, mixed populations of anergized and apoptosing T cells can be found. In some cases, anergy appears to lead to death while, in other instances, cells revert to a functional state. This review focuses on recent papers examining each of these topics in an attempt to obtain a preliminary integrated picture of immune regulation in autoimmune diseases.

    View details for Web of Science ID A1994PZ42600018

    View details for PubMedID 7710719

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