Lawrence Steinman, MD

Publication Details

  • PATHOGEN ANTIGEN-REACTIVE AND SUPERANTIGEN-REACTIVE SYNOVIAL-FLUID T-CELLS IN REACTIVE ARTHRITIS JOURNAL OF INFECTIOUS DISEASES Lahesmaa, R., SODERBERG, C., BLISKA, J., ALLSUP, A., Luukkainen, R., Steinman, L., Uchiyama, T., Peltz, G. 1995; 172 (5): 1290-1297

    Abstract:

    Analysis of pathogen-reactive T cell clones (CD3+4+8-TCR alpha beta +), isolated from the synovial fluid of 2 HLA-B27-positive patients with Yersinia enterocolitica-triggered reactive arthritis, has provided important information about the cellular immune response to this disease-inciting pathogen. This study demonstrates that the proteins secreted by Y. enterocolitica, including a protein with tyrosine phosphatase activity (YopH), are potent immunogens stimulating CD4+ cells within the inflamed joint. The pathogen-reactive T cell clones preferentially utilized a limited set of T cell receptor variable region gene segments. A purified Yersinia superantigen triggered a proliferative response in most of the antigen-reactive T cell clones tested. These results suggest that the activity of this pathogen's superantigen influences the cellular immune response to its antigens.

    View details for Web of Science ID A1995TA55200016

    View details for PubMedID 7594666

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