C. Andrew Bonham

Publication Details

  • Inhibition of T lymphocyte activation and apoptotic cell death by cyclosporin A and tacrolimus (FK506) - Its relevance to therapy of HIV infection Thomson, A. W., Bonham, C. A. PLENUM PRESS DIV PLENUM PUBLISHING CORP. 1995: 211-216


    Theoretically, drugs that inhibit programmed cell death could be used to inhibit the increased apoptotic decay of lymphocyte populations in human immunodeficiency virus (HIV) infection. The concept that immunopathologic processes cause immune suppression provides a further rationale for the use of agents such as cyclosporin A (CsA) or tacrolimus (formerly known as FK506) early in HIV infection to reduce cytotoxic CD8+ T cell-mediated destruction of HIV-infected target cells.

    View details for Web of Science ID A1995BD53D00018

    View details for PubMedID 7572394

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