Philip A. Pizzo, M.D.

Publication Details

  • EFFECTS OF MACROPHAGE-COLONY-STIMULATING FACTOR ON ANTIFUNGAL ACTIVITY OF MONONUCLEAR PHAGOCYTES AGAINST ASPERGILLUS-FUMIGATUS JOURNAL OF INFECTIOUS DISEASES Roilides, E., Sein, T., Holmes, A., Chanock, S., Blake, C., Pizzo, P. A., Walsh, T. J. 1995; 172 (4): 1028-1034

    Abstract:

    The effects of recombinant human macrophage colony-stimulating factor (M-CSF) on antifungal activity of human monocytes (MNC), MNC-derived macrophages (MDM), and rabbit pulmonary alveolar macrophages (PAM) against Aspergillus fumigatus were studied. MNC-induced hyphal damage was augmented by incubation with M-CSF (P = .027); PAM-induced hyphal damage was moderately enhanced by M-CSF (P = .046). Phagocytosis of Aspergillus conidia by MDM and PAM was strongly enhanced by M-CSF (P < .01). MNC pretreated with M-CSF exhibited enhanced superoxide anion production in response to PMA (P = .026). This effect was not associated with increased levels of mRNA transcripts of the components of NADPH oxidase, the enzyme responsible for superoxide anion production. M-CSF augments antifungal activity of mononuclear phagocytes against both conidia and hyphae of Aspergillus fumigatus partly by enhancement of oxidation-dependent mechanisms and may have an important immunomodulatory role in prevention and treatment of invasive aspergillosis in leukopenic patients.

    View details for Web of Science ID A1995RW06200017

    View details for PubMedID 7561176

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