Philip A. Pizzo, M.D.

Publication Details

  • DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH GRANULOCYTE-COLONY-STIMULATING FACTOR THERAPY IN A CHILD WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION JOURNAL OF PEDIATRICS Mueller, B. U., Burt, R., Gulick, L., Jacobsen, F., Pizzo, P. A., Horne, M. 1995; 126 (5): 749-752

    Abstract:

    We report a case of disseminated intravascular coagulopathy, apparently caused by exposure to granulocyte colony-stimulating factor (G-CSF). The medical records of patients treated for more than 30 consecutive days with subcutaneously administered G-CSF were reviewed for the occurrence of thrombocytopenia or coagulation abnormalities. New-onset thrombocytopenia with a platelet count less than 100 x 10(9) cells/L (< 100,000 cells/mm3) developed in 9 of 23 patients (39%) after a median of 11 weeks of treatment with G-CSF at dosages between 1 and 10 micrograms/kg per day.

    View details for Web of Science ID A1995QY15100012

    View details for PubMedID 7538574

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