Glenn Rosen

Publication Details

  • THE INTEGRIN ALPHA-4-BETA-1 AND ITS COUNTER-RECEPTOR VCAM-1 IN DEVELOPMENT AND IMMUNE FUNCTION Dean, D. C., Iademarco, M. F., Rosen, G. D., Sheppard, A. M. AMER THORACIC SOC. 1993: S43-S46

    Abstract:

    The integrin alpha 4 beta 1 and its counter receptor vascular cell adhesion molecule-1 (VCAM-1) mediate well-described cell-cell interactions that are critical for immune function. However, these receptors also mediate cell-cell interactions that are important for skeletal muscle differentiation. We have found that contrasting transcriptional mechanisms control their patterns of expression in the immune system and in muscle. Recent studies indicate that alpha 4 beta 1 and VCAM-1 are also expressed in a number of developing tissues, implying that these receptors have a general role in facilitating cell-cell interactions during development.

    View details for Web of Science ID A1993NH92300005

    View details for PubMedID 7504895

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