Greer Murphy M.D., Ph.D.

Publication Details

  • EXPRESSION OF INTERLEUKIN-11 AND ITS ENCODING MESSENGER-RNA BY GLIOBLASTOMA CELLS NEUROSCIENCE LETTERS Murphy, G. M., Bitting, L., Majewska, A., Schmidt, K., Song, Y. L., Wood, C. R. 1995; 196 (3): 153-156


    Interleukin-11 (IL-11) is a pleiotropic cytokine with important effects on hematopoietic and other cells. IL-11 was originally described as a product of stromal cell lines and fibroblasts. Using RT-PCR, Northern blotting, and ELISA we demonstrated that the human U373 and U87 glioblastoma cell lines expressed IL-11 and its encoding mRNA when stimulated with IL-1 beta, phorbol ester, and calcium ionophore. The neuroblastoma cell line SH-SY5Y did not express IL-11 mRNA in response to these agents. Cerebral expression of IL-11 by glial cells is important because IL-11 has been shown to have effects on neuronal electrophysiology, has overlapping functions with the neuroactive cytokine interleukin-6, and is part of the gp130-associated neuropoietic family of cytokines.

    View details for Web of Science ID A1995RU16500003

    View details for PubMedID 7501271

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