Frank M. Longo

Publication Details

  • BRAIN INJURY CAUSES A TIME-DEPENDENT INCREASE IN NEURONOTROPHIC ACTIVITY AT THE LESION SITE SCIENCE NIETOSAMPEDRO, M., Lewis, E. R., Cotman, C. W., MANTHORPE, M., Skaper, S. D., Barbin, G., LONGO, F. M., VARON, S. 1982; 217 (4562): 860-861

    Abstract:

    A cavity was made in the brain (entorhinal cortex) of developing or adult rats, and a small piece of Gelfoam was emplaced to collect fluid secreted into the wound. The neuronotrophic activity of the fluid was assayed with sympathetic and parasympathetic neurons in culture. The results show that wounds in the brain of developing or adult rats stimulate the accumulation of neuronotrophic factors and that the activity of these factors increases over the first few days after infliction of the damage.

    View details for Web of Science ID A1982PC11800039

    View details for PubMedID 7100931

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