Barbara Sommer

Publication Details

  • CIRCADIAN CHANGES IN THE DISTRIBUTION AND EFFECTS OF HALOPERIDOL IN THE RAT NEUROPHARMACOLOGY Campbell, A., Herschel, M., Sommer, B., Madsen, J. R., Cohen, B. M., BALDESSARINI, R. J. 1982; 21 (7): 663-669

    Abstract:

    Striking circadian changes in behavioral sensitivity to haloperidol were found by measurements of cataleptic responses in rats trained in a controlled lighting cycle (lights on, 7:00 a.m.--7:00 p.m.). Thus, catalepsy was maximal at about 4:00 p.m. and minimal at about 4:00 a.m., virtually the opposite of the circadian rhythm of spontaneous behavioral activity in drug-free rats. At a given dose of haloperidol, catalepsy scores differed 2- to 3-fold, and the ED50 shifted left nearly 10-fold from a.m. to p.m. After fixed doses of haloperidol, tissue levels of the drug, as determined by a sensitive and selective radioreceptor assay, differed by 2- to 6-fold through the 24 hr cycle and brain levels closely followed the circadian changes in behavior. These results suggest a pharmacokinetic contribution to the circadian changes in behavioral response, although additional pharmacodynamic factors are also considered.

    View details for Web of Science ID A1982PB21200009

    View details for PubMedID 6889690

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