John W. Farquhar, M.D.

Publication Details

  • DOES WEIGHT-LOSS CAUSE THE EXERCISE-INDUCED INCREASE IN PLASMA HIGH-DENSITY LIPOPROTEINS ATHEROSCLEROSIS Williams, P. T., Wood, P. D., Krauss, R. M., Haskell, W. L., Vranizan, K. M., Blair, S. N., Terry, R., Farquhar, J. W. 1983; 47 (2): 173-185


    Studies showing an increase in plasma concentration of high density lipoprotein cholesterol (HDL-C) with moderate exercise have usually rejected the role of body weight change in the HDL-C raising process, ostensibly because the amount of weight lost has been negligible. To investigate HDL-C changes more thoroughly, we followed initially sedentary middle-aged men randomly assigned to either a moderate running (n = 36) or a sedentary control (n = 28) group for one year. Among runners, one-year changes in plasma HDL-C concentrations correlated strongly with their body weight changes (r = - 0.53, P less than 0.001). Curve-fitting procedures and regression analysis suggested that processes associated with weight change produce much of the plasma HDL-C changes induced by moderate exercise and that changes in HDL-C concentration predominantly reflect changes in the reputedly anti-atherogenic HDL2 sub-component. Further, the interaction between weight change and plasma HDL-C concentration was significantly different (P less than 0.001) in exercisers and controls suggesting that the metabolic consequences of exercise-induced weight change are different from the consequences of weight change in the sedentary state.

    View details for Web of Science ID A1983QR12900006

    View details for PubMedID 6870998

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