Michael S. B. Edwards M.D.

Publication Details

  • EVALUATION OF MISONIDAZOLE PERIPHERAL NEUROTOXICITY IN RATS BY ANALYSIS OF NERVE TRAINS EVOKED-RESPONSE INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS Edwards, M. S., BOLGER, C. A., Levin, V. A., Phillips, T. L., Jewett, D. L. 1982; 8 (1): 69-74

    Abstract:

    The clinical use of misonidazole and other nitroimidazole radiosensitizing agents is limited by the peripheral and central neurotoxicity that is produced in animals and humans. In a blinded study, rats treated with misonidazole at either 100 mg/kg or 300 mg/kg, 5 days/week for 3 weeks, were evaluated for peripheral neurotoxicity using nerve trains evoked responses. Only one rat treated at a dose of 100 mg/kg developed symptoms and signs of neurotoxicity, while all rats treated at 300 mg/kg developed these signs and symptoms. Nerve trains analysis made possible a diagnosis of neurotoxicity before overt clinical signs appeared. This test is non-invasive and may be useful for evaluating patients receiving nitroimidazole radiosensitizers as part of a radiation therapy regimen.

    View details for Web of Science ID A1982NC48800011

    View details for PubMedID 6277833

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