Gary Schoolnik

Publication Details

  • A COMMON ANTIGENIC DETERMINANT FOUND IN 2 FUNCTIONALLY UNRELATED TOXINS JOURNAL OF EXPERIMENTAL MEDICINE Gariepy, J., OHANLEY, P., Waldman, S. A., Murad, F., SCHOOLNIK, G. K. 1984; 160 (4): 1253-1258

    Abstract:

    The heat-stable enterotoxin ST Ib produced by enterotoxigenic E. coli strains shares a sequence homology with the sea snail neurotoxin, conotoxin GI. Rabbit antisera were raised against synthetic analogs of these toxins and to a six-residue peptide representing the region common to both toxins. Results from enzyme-linked immunosorbent assays indicate that the homologous region of both toxins represents part of their antigenic site. The lack of cross-reactivity exhibited by the six-residue common domain with serum directed against either toxin suggests that this region probably retains a similar conformation in the intact toxins but not in the isolated fragment.

    View details for Web of Science ID A1984TM66100023

    View details for PubMedID 6207263

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