Matt van de Rijn

Publication Details

  • BIOCHEMICAL-COMPARISON OF THE T6-ANTIGEN AND HLA-A,B-ANTIGENS HUMAN IMMUNOLOGY Lerch, P. G., VANDERIJN, M., SCHRIER, P., TERHORST, C. 1983; 6 (1): 13-30

    Abstract:

    The human thymic differentiation antigen T6, which was found to be associated with beta 2-microglobulin, was compared to the HLA-A,B antigens. Using a heteroantiserum prepared against denatured heavy chains of HLA-A,B antigens, no cross-reactivity with denatured T6 could be detected. The molecular weight of the protein backbone of T6 was found to be 34,000 as compared to 40,000 for the HLA-A,B antigens. Also, not only was the percentage of carbohydrate of T6 (25-35%) different from the HLA-A,B antigens (10%), but lectin binding studies showed that their sugar composition may differ. The two forms of T6, which previously had been found on MOLT-4 cells, appeared to have different levels of glycosylation, but apparently had the same protein backbone. T6, like HLA, has a hydrophobic domain, since it could be labeled with [125I]iodonaphthylazide. We conclude from these studies that T6 may be a class I MHC antigen which is different from the classical HLA-A,B antigens.

    View details for Web of Science ID A1983QB62200002

    View details for PubMedID 6187718

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