Uta Francke

Publication Details

  • THE INVOLVEMENT OF 6P IN MELANOMA CANCER GENETICS AND CYTOGENETICS Cowan, J. M., Halaban, R., Lane, A. T., FRANCKE, U. 1986; 20 (3-4): 255-261


    Karyotype analysis of first passage cells from a melanoma, occurring in a patient with a giant congenital nevus, revealed monosomy of chromosomes #6 and #11, and trisomy of chromosomes #8 and #22. Five marker chromosomes were present, including two ring chromosomes. The origin of three of the marker chromosomes was determined, and all were found to contain the region 6p21.1-6p23. The ring chromosomes were also thought to contain this region, to which the major histocompatibility locus has been mapped. The significance of these findings is discussed in the light of recent reports of chromosome studies of melanoma cells.

    View details for Web of Science ID A1986AZK1300008

    View details for PubMedID 3943065

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