Hugh O'Brodovich

Publication Details

  • MEASUREMENT OF PULMONARY EPITHELIAL PERMEABILITY WITH TC-99M-DTPA AEROSOL SEMINARS IN NUCLEAR MEDICINE Coates, G., OBRODOVICH, H. 1986; 16 (4): 275-284

    Abstract:

    The rate at which inhaled aerosol of 99mTc-diethylenetriamine pentaacetate (DTPA) leaves the lung by diffusion into the vascular space can be measured with a gamma camera or simple probe. In normal humans, 99mTc-DTPA clears from the lung with a half time of about 80 minutes. Many acute and chronic conditions that alter the integrity of the pulmonary epithelium cause an increased clearance rate. Thus cigarette smoking, alveolitis from a variety of causes, adult respiratory distress syndrome (ARDS), and hyaline membrane disease (HMD) in the infant have all been shown to be associated with rapid pulmonary clearance of 99mTc-DTPA. Rapid clearance is also promoted by increased lung volume and decreased surfactant activity. Although the mechanism of increased clearance in pathological states is not known, the 99mTc-DTPA lung-clearance technique has great potential clinically, particularly in patients at risk from ARDS and HMD and in the diagnosis and follow-up of alveolitis.

    View details for Web of Science ID A1986E973300004

    View details for PubMedID 3541208

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