Bertil Glader

Publication Details

  • ELEVATED RED-CELL ADENOSINE-DEAMINASE ACTIVITY - A MARKER OF DISORDERED ERYTHROPOIESIS IN DIAMOND-BLACKFAN ANEMIA AND OTHER HEMATOLOGIC DISEASES BRITISH JOURNAL OF HAEMATOLOGY Glader, B. E., BACKER, K. 1988; 68 (2): 165-168

    Abstract:

    Red-cell adenosine deaminase (ADA) activity in children with Diamond-Blackfan anaemia is significantly increased (1.91 +/- 0.90 U/g Hb) compared to that seen in transient erythroblastopenia of childhood (0.80 +/- 0.16 U/g Hb) or normal individuals (0.61 +/- 0.13 U/g). These data thus further support that measurement of this purine metabolic enzyme is useful in diagnosing the cause of pure RBC aplasia in children. Of interest, however, elevated RBC-ADA activity also is seen in some children with acute leukaemia and other haematologic disorders. In children with acute lymphoblastic leukaemia (ALL), the increase in RBC-ADA activity is proportional to the degree of anaemia. However, the elevated RBC-ADA activity in this leukaemic population is not related to the fetal haemoglobin concentration. These data suggest increased RBC-ADA activity may be a non-specific manifestation of abnormal erythroid stem cell function, an alteration distinct from that seen with reactivation of fetal erythropoiesis. However, since almost all patients with Diamond-Blackfan anaemia manifest elevated RBC-ADA activity, this chemical alteration yet may reflect the specific erythroid differentiation lesion in this disorder.

    View details for Web of Science ID A1988M011900004

    View details for PubMedID 3348976

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