Richard Sibley

Publication Details

  • SECONDARY NEURO-ENDOCRINE CARCINOMAS OF THE SKIN JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY WICK, M. R., Millns, J. L., Sibley, R. K., PITTELKOW, M. R., Winkelmann, R. K. 1985; 13 (1): 134-142

    Abstract:

    Since the initial clinical presentation of visceral neuroendocrine carcinoma is occasionally a cutaneous metastasis, diagnostic confusion with primary neuroendocrine carcinoma of the skin (Merkel cell carcinoma) may ensue. In this study, seven cases of secondary cutaneous neuroendocrine carcinoma were immunohistochemically compared with twenty-one Merkel cell carcinomas for ten antigenic moieties that have been associated with endocrine tumors. Six of seven secondary tumors stained for bombesin, leucine enkephalin, methionine enkephalin, or beta-endorphin, none of which was detected in the primary cutaneous neuroendocrine carcinomas. These data suggest that immunohistochemical study may be useful in separating primary from secondary neuroendocrine tumors of the skin and may assist in directing clinical attention to the most probable site of visceral neoplasia.

    View details for Web of Science ID A1985ALL5100020

    View details for PubMedID 3161911

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