Uta Francke

Publication Details

  • CYTOGENETIC AND MOLECULAR GENETIC-STUDIES OF A PATIENT WITH ATYPICAL LYMPHOID HYPERPLASIA CANCER GENETICS AND CYTOGENETICS CHENEVIXTRENCH, G., Cowan, J. M., Behm, F. G., Goorha, R., BROWN, J. A., Westin, E. H., FRANCKE, U. 1987; 27 (2): 251-259

    Abstract:

    We have karyotyped cells from a lymph node of a patient with atypical lymphoid hyperplasia. Among other clonal chromosomal abnormalities, a t(2;19) translocation was observed with breakpoints at 2p11.2 and 19q13. The genes for transforming growth factor alpha and beta have been mapped to 2p11-p13 and 19q13, respectively, but Southern blot analysis did not reveal any alteration in the structure of these genes. Similarly, the kappa immunoglobulin gene, which maps to 2p11-p12 was not rearranged. In addition, Southern blot analysis using immunoglobulin and T-cell receptor genes as probes, did not demonstrate any clonality of either B or T cells. We propose that this patient represents an early, polyclonal stage of atypical hyperplasia. The chromosome changes observed may have been one of the etiologic factors causing this disorder.

    View details for Web of Science ID A1987J268500007

    View details for PubMedID 3036340

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