Uta Francke

Publication Details

  • GENETIC AND CYTOGENETIC LOCALIZATION OF THE HOMEO BOX CONTAINING GENES ON MOUSE CHROMOSOME-6 AND HUMAN CHROMOSOME-7 EMBO JOURNAL Bucan, M., YANGFENG, T., COLBERGPOLEY, A. M., Wolgemuth, D. J., Guenet, J. L., FRANCKE, U., Lehrach, H. 1986; 5 (11): 2899-2905

    Abstract:

    Probes from the m6 homeo box cluster were mapped to mouse chromosome 6 by somatic cell genetics, in situ hybridisation, and by a Mus spretus--Mus musculus backcross mapping system. In addition, the testis-specific homeo box containing cDNA, clone, HBT-1, has been mapped using the same back-cross system and the B X D recombinant inbred strain set. Close genetic and physical linkage between the m6 cluster and HBT-1 was demonstrated, positioning these sequences to the same local cluster of homeo box containing genes. The map location of this cluster between IgK and Tcrb coincides with the morphological mutation hypodactyly (Hd). Synteny has been observed between a region of mouse chromosome 6 and the long arm of human chromosome 7 encompassing the markers Cpa, Tcrb and Try-1. Here we localise human sequences hybridising to the mouse m6 probes to the short arm of chromosome 7, breaking the region of synteny.

    View details for Web of Science ID A1986E782500023

    View details for PubMedID 2878803

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