Gary Schoolnik

Publication Details

  • STRUCTURE-FUNCTION ANALYSIS OF PROTEIN ACTIVE-SITES WITH ANTIIDIOTYPIC ANTIBODY METHODS IN ENZYMOLOGY Ludwig, D. S., SCHOOLNIK, G. K. 1989; 178: 163-171

    Abstract:

    Antigen and internal image-bearing anti-idiotypic antibody, owing to potential differences in size and chemical nature, need not necessarily demonstrate identical binding specificities. Such differences, termed "dissociability," may be exploited in structure-function analysis of receptor-ligand interaction to identify functionally important amino acid residues, define receptor class, or distinguish receptor conformation. In this sense, ligand and the anti-idiotypes they elicit constitute alternative and complementary probes of protein active sites.

    View details for Web of Science ID A1989CX43700011

    View details for PubMedID 2601623

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