Ann M. Arvin

Publication Details

  • NEONATAL ANTIBODY-DEPENDENT CELLULAR CYTO-TOXIC ANTIBODY-LEVELS ARE ASSOCIATED WITH THE CLINICAL PRESENTATION OF NEONATAL HERPES-SIMPLEX VIRUS-INFECTION JOURNAL OF INFECTIOUS DISEASES Kohl, S., West, M. S., Prober, C. G., Sullender, W. M., Loo, L. S., Arvin, A. M. 1989; 160 (5): 770-776

    Abstract:

    The role of antiviral antibodies in protection against neonatal herpes simplex virus (HSV) infection remains controversial. The relationship between neonatal and maternal anti-HSV antibodies and disease presentation was analyzed in 47 babies. Of the neonates, 77% had localized and 23% had disseminated HSV infection. Antibody-dependent cellular cytotoxic (ADCC) antibodies were evaluated in comparison with HSV neutralizing antibodies. High maternal (greater than 1:10(4)) or neonatal (greater than 1:10(3)) anti-HSV ADCC antibody levels or high neonatal antiviral neutralizing levels (greater than 1:20) were independently associated with an absence of disseminated HSV infection. Cochran-Mantel-Haenszel analysis demonstrated that ADCC levels were associated with disease status (P less than .02) while controlling for the level of neutralizing antibody.

    View details for Web of Science ID A1989AY21800005

    View details for PubMedID 2553825

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