David A. Relman

Publication Details

  • FILAMENTOUS HEMAGGLUTININ OF BORDETELLA-PERTUSSIS - NUCLEOTIDE SEQUENCE AND CRUCIAL ROLE IN ADHERENCE PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Relman, D. A., Domenighini, M., Tuomanen, E., Rappuoli, R., FALKOW, S. 1989; 86 (8): 2637-2641

    Abstract:

    Filamentous hemagglutinin is a surface-associated adherence protein of Bordetella pertussis, which is a component of some new acellular pertussis vaccines. The nucleotide sequence of an open reading frame that encompasses the filamentous hemagglutinin structural gene, fhaB, suggests that proteolytic processing is necessary to generate the mature 220-kDa filamentous hemagglutinin product. An Arg-Gly-Asp (RGD) tripeptide is found within filamentous hemagglutinin that may be involved in its adherence properties. An internal in-frame deletion in fhaB, encompassing the RGD region, causes loss of B. pertussis-binding to ciliated eukaryotic cells, confirming a potential role for this protein in host-cell binding and infection.

    View details for Web of Science ID A1989U231400025

    View details for PubMedID 2539596

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