Samuel Strober

Publication Details

  • TOTAL LYMPHOID IRRADIATION REDUCES IGG AUTOANTIBODY PRODUCTION AND ENHANCES SPECIFIC ANTIBODY-RESPONSES IN NZB/NZW F1-MICE CELLULAR IMMUNOLOGY Farinas, M. C., Strober, S. 1989; 121 (2): 423-432

    Abstract:

    Thymus-independent primary antibody responses were studied in young and old (9 months) untreated and TLI-treated NZB/NZW and BALB/c mice. Untreated old NZB/NZW mice had a low primary response to Brucella abortus (BA) as compared to that of young NZB/NZW and BALB/c mice. However, TLI treatment resulted in a 130-fold increase in the IgG anti-BA primary antibody response at day 21 postimmunization, achieving similar levels to those of young NZB/NZW or nonautoimmune BALB/c mice. Anti-TNP responses to trinitrophenylated BA or Ficoll were masked by high background levels of anti-TNP antibodies. Despite the increase in the anti-BA response, spontaneous immunoglobulin secretion and autoantibody levels were markedly decreased after TLI in old NZB/NZW mice.

    View details for Web of Science ID A1989AD23900022

    View details for PubMedID 2500257

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