Richard Sibley

Publication Details

  • PEANUT LECTIN BINDING IN BREAST-CARCINOMA - LACK OF CORRELATION WITH ESTROGEN-RECEPTOR CONTENT CANCER Stanley, M. W., Kiang, D. T., Sibley, R. K. 1986; 58 (9): 2046-2051

    Abstract:

    Previous reports have shown binding of peanut agglutinin (PNA) by immunoperoxidase techniques in normal, benign proliferative, and malignant breast epithelia. Correlation of binding with maturity, secretory activity, hormonal milieu, and tissue hormone receptor content has been described. To investigate the relationship between PNA staining by the avidin-biotin complex technique and estrogen receptor (ER) content, 79 breast tumors of different types and known tissue ER content were studied. Thirty-eight of 50 ER-positive cases were PNA-positive. Twenty of 29 ER-negative cases were PNA-positive. Statistical analysis shows the two factors to be independent (0.5 less than P less than 0.9). The literature on blood group antigens in breast carcinoma and histochemical applications of PNA is reviewed.

    View details for Web of Science ID A1986E493900014

    View details for PubMedID 2428465

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