Lawrence Steinman

Publication Details

  • PREDOMINANT EXPRESSION OF T-CELL RECEPTOR-V-ALPHA-7 IN TUMOR-INFILTRATING LYMPHOCYTES OF UVEAL MELANOMA SCIENCE NITTA, T., Oksenberg, J. R., Rao, N. A., Steinman, L. 1990; 249 (4969): 672-674

    Abstract:

    Expression of T cell receptor (TCR) V alpha genes in tumor-infiltrating lymphocytes (TILs) within intraocular melanoma was studied. Primers for 18 different human TCR V alpha families were used to analyze TCR V alpha-C alpha gene rearrangements in TIL in these melanomas obtained at surgery. A limited number of TCR V alpha genes were expressed and rearranged in these tumors, and TILs expressing V alpha 7 were found in seven of eight of these uveal melanomas. TCR gene usage is also restricted in experimental autoimmune disease, in T cells within organs like skin and other epithelial tissues, and in the brain of patients with multiple sclerosis (MS). The restricted usage of TCR genes in TIL may indicate that a specific antigen in these melanomas is targeted.

    View details for Web of Science ID A1990DT79600044

    View details for PubMedID 2382141

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