Adam Frymoyer

Publication Details

  • Desired Vancomycin Trough Serum Concentration for Treating Invasive Methicillin-resistant Staphylococcal Infections. Pediatric infectious disease journal Frymoyer, A., Guglielmo, B. J., Hersh, A. L. 2013; 32 (10): 1077-1079


    Vancomycin AUC/MIC >400 best predicts outcome when treating invasive MRSA infection, however trough serum concentrations are used clinically to assess the appropriateness of dosing. We used pharmacokinetic modeling and simulation to examine the relationship between vancomycin trough values and AUC/MIC in children receiving vancomycin 15mg/kg every 6h and MRSA MIC of 1 μg/ml. A trough of 7-10 μg/ml predicted achievement of AUC/MIC >400 for >90% of children.

    View details for DOI 10.1097/INF.0b013e318299f75c

    View details for PubMedID 23652479

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