John S. Oghalai

Publication Details

  • In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography BIOMEDICAL OPTICS EXPRESS Gao, S. S., Raphael, P. D., Wang, R., Park, J., Xia, A., Applegate, B. E., Oghalai, J. S. 2013; 4 (2): 230-240


    Sound transduction within the auditory portion of the inner ear, the cochlea, is a complex nonlinear process. The study of cochlear mechanics in large rodents has provided important insights into cochlear function. However, technological and experimental limitations have restricted studies in mice due to their smaller cochlea. These challenges are important to overcome because of the wide variety of transgenic mouse strains with hearing loss mutations that are available for study. To accomplish this goal, we used spectral domain optical coherence tomography to visualize and measure sound-induced vibrations of intracochlear tissues. We present, to our knowledge, the first vibration measurements from the apex of an unopened mouse cochlea.

    View details for Web of Science ID 000314806600006

    View details for PubMedID 23411442

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