Lawrence Steinman

Publication Details

  • Inflammatory Cytokines at the Summits of Pathological Signal Cascades in Brain Diseases SCIENCE SIGNALING Steinman, L. 2013; 6 (258)


    When considering the hierarchical organization of pathological signaling cascades in immunological disorders of the brain, certain cytokines might be considered pinnacles of pathophysiological importance, with their presence determining the appearance or the course of a particular disease. Interleukin-1 (IL-1), IL-6, IL-17, and tumor necrosis factor are critical for the pathogenesis of inflammation in specific brain disorders. Targeting these cytokines or their receptors can alter the course of several neurological diseases, but the effects may be beneficial or harmful.

    View details for DOI 10.1126/scisignal.2003898

    View details for Web of Science ID 000313649300003

    View details for PubMedID 23322904

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