Samuel Strober

Publication Details

  • LY-1 B-CELLS AND DISEASE-ACTIVITY IN (NEW-ZEALAND BLACK X NEW-ZEALAND WHITE) F1-MICE - EFFECT OF TOTAL LYMPHOID IRRADIATION ARTHRITIS AND RHEUMATISM Farinas, M. C., STALL, A. M., SOLOVERA, J. J., Tarlinton, D. M., Herzenberg, L. A., Strober, S. 1990; 33 (4): 553-562

    Abstract:

    The treatment of female (New Zealand black x New Zealand white)F1 mice with total lymphoid irradiation resulted in a prolonged remission of autoimmune disease activity. Total lymphoid irradiation-treated mice also showed a marked reduction of Ly-1 B cells, which lasted up to 3 months. The subsequent return of Ly-1 B cells to preirradiation levels was not associated with a simultaneous return of disease when measured by parameters such as IgG anti-DNA antibodies and spontaneous secretion of IgG by splenic cells. In cell sorting experiments, most of the cells spontaneously secreting IgG were found within the Ly-1- (CD5-) splenic B cell population.

    View details for Web of Science ID A1990CZ97400013

    View details for PubMedID 2328033

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