Michael Amylon

Publication Details

  • REPOPULATION OF MARROW AFTER TRANSPLANTATION - MR IMAGING WITH PATHOLOGICAL CORRELATION RADIOLOGY Stevens, S. K., Moore, S. G., Amylon, M. D. 1990; 175 (1): 213-218

    Abstract:

    Sixty-seven magnetic resonance (MR) studies of the lumbar spine were performed in 15 patients with bone marrow transplants, and the appearance of marrow regeneration on MR images was correlated with results of bone marrow biopsy and pathologic examination. After transplantation, T1-weighted MR images of vertebral marrow showed a characteristic band pattern consisting of a peripheral zone of intermediate signal intensity and a central zone of bright signal intensity. Reciprocal changes were identified on short inversion time inversion recovery images. At histologic examination the central zone corresponded to fatty marrow; the peripheral zone corresponded to a zone of regenerating hematopoietic cells. Posttransplantation T1 and T2 relaxation times of the entire vertebral marrow were calculated from the spin-echo images; no statistically significant trends in relaxation times were noted. Knowledge of the normal MR pattern of marrow regeneration after transplantation may be useful in screening for residual marrow disease, determining marrow engraftment, and differentiating marrow repopulation with normal versus malignant cells.

    View details for Web of Science ID A1990CV27100038

    View details for PubMedID 2315483

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