Lawrence Steinman

Publication Details

  • The discovery of natalizumab, a potent therapeutic for multiple sclerosis JOURNAL OF CELL BIOLOGY Steinman, L. 2012; 199 (3): 413-416


    Multiple sclerosis (MS) is the major inflammatory demyelinating disease of the central nervous system. There is strong evidence that an immune response in the brain is a critical component of the disease. In 1992, in a collaboration between academia and biotechnology, my colleagues and I showed that ?4 integrin was the critical molecule involved in the homing of immune cells into the inflamed brain. Was it sheer luck that these results led to the development of a drug for MS?

    View details for DOI 10.1083/jcb.201207175

    View details for Web of Science ID 000310580500004

    View details for PubMedID 23109666

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