Michael Greicius

Publication Details

  • Gender Modulates the APOE epsilon 4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels JOURNAL OF NEUROSCIENCE Damoiseaux, J. S., Seeley, W. W., Zhou, J., Shirer, W. R., Coppola, G., Karydas, A., Rosen, H. J., Miller, B. L., Kramer, J. H., Greicius, M. D. 2012; 32 (24): 8254-8262


    We examined whether the effect of the apolipoprotein E (APOE) genotype on functional brain connectivity is modulated by gender in healthy older human adults. Our results confirm significantly decreased connectivity in the default mode network in healthy older APOE ?4 carriers compared with ?3 homozygotes. More important, further testing revealed a significant interaction between APOE genotype and gender in the precuneus, a major default mode hub. Female ?4 carriers showed significantly reduced default mode connectivity compared with either female ?3 homozygotes or male ?4 carriers, whereas male ?4 carriers differed minimally from male ?3 homozygotes. An additional analysis in an independent sample of healthy elderly using an independent marker of Alzheimer's disease, i.e., spinal fluid levels of tau, provided corresponding evidence for this gender-by-APOE interaction. Together, these results converge with previous work showing a higher prevalence of the ?4 allele among women with Alzheimer's disease and, critically, demonstrate that this interaction between APOE genotype and gender is detectable in the preclinical period.

    View details for DOI 10.1523/JNEUROSCI.0305-12.2012

    View details for Web of Science ID 000305295600017

    View details for PubMedID 22699906

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