Despina Contopoulos-Ioannidis, MD

Publication Details

  • Pathways for inappropriate dispensing of antibiotics for rhinosinusitis: A randomized trial CLINICAL INFECTIOUS DISEASES Contopoulos-Ioannidis, D. G., Koliofoti, I. D., Koutroumpa, I. C., Giannakakis, I. A., Ioannidis, J. P. 2001; 33 (1): 76-82


    We evaluated the extent of and factors that determine the inappropriate use of antibiotics that are obtained without a physician's prescription. Ninety-eight Greek pharmacists were visited by actress-researchers who played clients requesting antibiotics without a physician's prescription. Pharmacists were randomly challenged in a scenario that involved simulated cases of acute uncomplicated rhinosinusitis with either low fever (38.5 degrees C) or high fever (40 degrees C). Antibiotics were offered by 34 (69%) of 49 pharmacists who were presented with the high-fever scenario and by 42 (86%) of 49 pharmacists who were presented with the low-fever scenario (risk difference, 16.3%; P = .05). Thirty-two (65%) and 35 (71%) pharmacists in the high- and low-fever study arms, respectively, agreed to sell the actress-researchers broad-spectrum antibiotics. Only 28 (57%) and 17 (35%) pharmacists, respectively, recommended that the patient visit a physician (P = .03). Inappropriate recommendations regarding antibiotic use were very common in the studied setting. Antibiotics were more likely to be offered to persons who did not have a prescription when they were less likely to be clinically indicated.

    View details for Web of Science ID 000169101500019

    View details for PubMedID 11389498

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