Clare J. Twist
Publication Details
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Effects of human monoclonal antibody 216 on B-progenitor acute lymphoblastic leukemia in vitro.
Pediatr Blood Cancer. 2007; (4): 380-6
Human monoclonal antibody (mAb) 216 is a naturally occurring IgM cytotoxic mAb that binds to a glycosylated epitope on the surface of B-lymphocytes. This study investigated if this mAb could bind and kill acute lymphoblastic leukemia (ALL) B-progenitor lymphoblasts in vitro. ALL cell lines were used to determine if combining mAb 216 with chemotherapeutic drugs would enhance killing and cell lines were used to measure cytotoxicity by mAb 216 with human complement.
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